In 1969 Leandro Manzo was born in Rio Gallegos, Santa Cruz, Argentina. At 13 he had his first group exhibition at the Museo de Artes Visuales de Quilmes, in Buenos Aires. From 1991 to 1993 Leandro worked in drawing and painting with renowned artist Martínez Howard who had studied with Lino Spilimbergo and the great Hungarian artist Lajo Szalay. He has worked alongside some of the most important Argentine artists of his time, including the late Leopoldo Presas, who included some of Leandro's works in his own collection. Since 2004 he has lived in various cities within the United States. In 2006 he received permanent residence for Exceptional Aptitude in the Field of the Arts.

His works can be found in Buenos Aires, Sao Paulo, Cuenca, Amsterdam, Barcelona, London, Madrid, Paris, Vienna, Zurich, Mexico City, Osaka, Tokyo and Toronto. In the United States his work is included in collections in Chicago, Los Angeles, Miami, New York City and Charlotte, NC, MOLAA Museum Long Beach, CA Permanent collection. His decorations and wall paintings are in Sao Paulo, Buenos Aires, New York City, Los Angeles and Charlotte, NC.