Ben-Simhon was born in Fez, Morocco in 1947, but his family immigrated to Israel upon the establishment of the state of in 1948. The artist grew up in the historic city of Jerusalem. He also served in the Israeli army before joining a group of friends to establish Kibbutz Eyal.

Israel was also the location of Ben-Simhon's extensive art education. In 1986, he studied at the acclaimed Avni Art Institute. In the next following years he immersed himself into the world of contemporary art at the highly acclaimed Kallisher Institute. Ben-Simhon soon became fascinated by the Fauvist and Cubist painters of the 19th Century, particularly by Picasso and Mogdigliani. Their influences are readily apparent in his paintings. His work is a balance between figurative and abstract, a perfect marriage of beauty and complication.

Today, Avi Ben-Simhon has become a highly collectible painter whose works can be found in private and corporate collections around the world. His collectors adore the bold lines and colorful harmony of his art which evokes a feeling of happiness and hope.